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Center for Systems Approaches to Infectious Diseases (JHU C-SAID)



The objective of C-SAID is to bring together Investigators with multidisciplinary backgrounds, including microbiology, immunology, genetics, next-generation sequencing, metabolomics, microbiome research, computational biology, and bioinformatics, to elucidate host-pathogen interactions underlying various infectious diseases. 

News & Upcoming Events

Monthly Journal Club:

Thursday, January 27

Ray lab will be presenting the Journal Club at 2 pm in CRB-II, conference room 212.

Click Here for the article.

Click here to join the meeting virtually.

Meeting ID: 951 3714 1735

Passcode: 648144

Latest Publications

High-throughput identification of Mycobacterium avium antibiotic tolerance genes

A genome-wide transposon screen was used to elucidate M. avium genes that play a role in the bacterium’s tolerance to first- and second-line antibiotics. A total of 193 unique M. avium mutants with significantly altered susceptibility to at least one of the four clinically used antibiotics tested, including two mutants (in DFS55_00905 and DFS55_12730) with panhypersusceptibility. The products of the antibiotic tolerance genes identified may represent novel targets for future drug development studies aimed at shortening the duration of therapy for MAC infections.

Click here for the article

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