JOHNS HOPKINS UNIVERSITY
Center for Systems Approaches to Infectious Diseases (JHU C-SAID)
The objective of C-SAID is to bring together Investigators with multidisciplinary backgrounds, including microbiology, immunology, genetics, next-generation sequencing, metabolomics, microbiome research, computational biology, and bioinformatics, to elucidate host-pathogen interactions underlying various infectious diseases.
News & Upcoming Events
Monthly Journal Club:
Thursday, January 27
Ray lab will be presenting the Journal Club at 2 pm in CRB-II, conference room 212.
Click Here for the article.
Click here to join the meeting virtually.
Meeting ID: 951 3714 1735
High-throughput identification of Mycobacterium avium antibiotic tolerance genes
A genome-wide transposon screen was used to elucidate M. avium genes that play a role in the bacterium’s tolerance to first- and second-line antibiotics. A total of 193 unique M. avium mutants with significantly altered susceptibility to at least one of the four clinically used antibiotics tested, including two mutants (in DFS55_00905 and DFS55_12730) with panhypersusceptibility. The products of the antibiotic tolerance genes identified may represent novel targets for future drug development studies aimed at shortening the duration of therapy for MAC infections.